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教員紹介

張馬 梅蕾(はりま めいれい)
職位 准教授
学位・資格 博士(医学)
所属(学部) 医療学部 リハビリテーション学科 共通専攻
学生へのメッセージ 豊かな人間性と広い見識、高い技術を有する医療従事者になるよう、充実な学校生活を送りましょう。
担当授業科目[大学] 内科学、生理学実習

プロフィール

学位の取得年 2000年
最終学歴 博士(医学)
所属学協会等 新潟医学会、日本薬学会

研究業績等

研究専門領域

内科学

研究課題

心疾患の発症メカニズムと治療、糖尿病及び合併症の漢方治療

社会的活動

国際交流委員会委員、倫理委員会委員

研究論文

2017年
1.Afrin R, Arumugam S, Rahman A, Wahed MI, Karuppagounder V, Harima M, Suzuki H, Miyashita S, Suzuki K, Yoneyama H, Ueno K, Watanabe K: Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-kB translocation. Int Immunopharmacol. 2017 Mar;44:174-182.

2.Afrin MR, Arumugam S, Rahman MA, Karuppagounder V, Sreedhar R, Harima M, Suzuki H, Nakamura T, Miyashita S, Suzuki K, Ueno K, Watanabe K: Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPKα and downregulation of STAT3 and caspase 3 dependent apoptotic pathways. Int Immunopharmacol. 2017 Feb;43:70-78.

3.Watanabe K, Sreedhar R, Thandavarayan RA, Karuppagounder V, Giridharan VV, Antony S, Harima M, Nakamura M, Suzuki K, Suzuki H, Sone H, Arumugam S. Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy. Biofactors. 2017 Mar;43(2):187-194.

2016年
1.Karuppagounder V, Arumugam S, Thandavarayan RA, Sreedhar R, Giridharan VV, Afrin R, Harima M, Miyashita S, Hara M, Suzuki K, Nakamura M, Ueno K, Watanabe K: Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats. Cytokine. 2016 Aug;84:1-9.

2.Pitchaimani V, Arumugam S, Thandavarayan RA, Karuppagounder V, Afrin MR, Sreedhar R, Harima M, Suzuki H, Miyashita S, Suzuki K, Nakamura M, Ueno K, Watanabe K: Hypothalamic glucagon signaling in fasting hypoglycemia. Life Sci. 2016 May 15;153:118-23.

3.Afrin R, Arumugam S, Wahed MI, Pitchaimani V, Karuppagounder V, Sreedhar R, Harima M, Suzuki H, Miyashita S, Nakamura T, Suzuki K, Nakamura M, Ueno K, Watanabe K: Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats. Am J Chin Med. 2016 Feb;44(1):87-101.

4.Karuppagounder V, Arumugam S, Thandavarayan RA, Sreedhar R, Giridharan VV, Pitchaimani V, Afrin R, Harima M, Krishnamurthy P, Suzuki K, Nakamura M, Ueno K, Watanabe K: Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model. Exp Dermatol. 2016 May;25(5):404-7.

2015年
1.Afrin R, Arumugam S, Soetikno V, Thandavarayan RA, Pitchaimani V, Karuppagounder V, Sreedhar R, Harima M, Suzuki H, Miyashita S, Nomoto M, Suzuki K, Watanabe K: Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats. Free Radical Research. 2015; 49(3): 279–289.

2.Meilei Harima, Somasundaram Arumugam, Juan Wen, Vigneshwaran Pitchaimani, Vengadeshprabhu Karuppagounder, Mst. Rejina Afrin, Remya Sreedhar, Shizuka Miyashita, Mayumi Nomoto, kazuyuki Ueno, masahiko Nakamura, Kenichi Watanabe: Effect of carvedilol against myocardial injury due to ischemia- reperfusion of the brain in rats. Experimental and Molecular Pathology. 2015;98:558-562.

3.Sreedhar R, Arumugam S, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin R, Miyashita S, Nomoto M, Harima M, Gurusamy N, Suzuki K, Watanabe K: Myocardial 14-3-3η protein protects against mitochondria mediated apoptosis. Cell Signal. 2015 Apr;27(4):770-6.

4.Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Nomoto M, Miyashita S, Suzuki K, Nakamura M, Watanabe K: Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Exp Dermatol. 2015 Jun;24(6):418-23.

5.Watanabe K, Arumugam S, Sreedhar R, Thandavarayan RA, Nakamura T, Nakamura M, Harima M, Yoneyama H, Suzuki K: Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy. Cell Signal. 2015 Jul;27(7):1517-24.

6.Arumugam S, Sreedhar R, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin MR, Miyashita S, Nomoto M, Harima M, Suzuki H, Nakamura T, Nakamura M, Suzuki K, Watanabe K: Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium. Cytokine. 2015 Aug;74(2):305-12.

7.Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Nomoto M, Miyashita S, Suzuki K, Nakamura M, Ueno K, Watanabe K: Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Jun 3.

8.Watanabe K, Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Suzuki K, Nakamura T, Nomoto M, Miyashita S, Fukumoto K, Ueno K: Pruni cortex ameliorates skin inflammation possibly through HMGB1-NFκB pathway in house dust mite induced atopic dermatitis NC/Nga transgenic mice. J Clin Biochem Nutr. 2015 May;56(3):186-94.

9.Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Suzuki K, Nakamura M, Ueno K, Watanabe K: Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation. Int Immunopharmacol. 2015 Sep;28(1):154-9.

10.Sreedhar R, Arumugam S, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin R, Harima M, Nakamura T, Ueno K, Nakamura M, Suzuki K, Watanabe K: Toki-shakuyaku-san, a Japanese kampo medicine, reduces colon inflammation in a mouse model of acute colitis. Int Immunopharmacol. 2015 Dec;29(2):869-75.

11.Sreedhar R, Arumugam S, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin R, Harima M, Nakamura M, Suzuki K, Gurusamy N, Krishnamurthy P, Watanabe K: Depletion of cardiac 14-3-3η protein adversely influences pathologic cardiac remodeling during myocardial infarction after coronary artery ligation in mice. Int J Cardiol. 2016 Jan 1;202:146-5.

12.Sreedhar R, Arumugam S, Karuppagounder V, Thandavarayan RA, Giridharan VV, Pitchaimani V, Afrin MR, Harima M, Nakamura T, Nakamura M, Suzuki K, Watanabe K: Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis. Int Immunopharmacol. 2015 Dec;29(2):957-63.

2014年
1.Gounder VK, Arumugam S, Arozal W, Thandavarayan RA, Pitchaimani V, Harima M, Suzuki K, Nomoto M, Watanabe K: Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats. Int Immunopharmacol. 2014 8(2):282-9 .

2.Arumugam S, Sreedhar R, Miyashita S, Karuppagounder V, Thandavarayan RA, Giridharan VV, Pitchaimani V, Afrin R, Harima M, Suzuki K, Watanabe K: Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy. Exp Mol Pathol. 2014 7(1):137-43 .

3.Pitchaimani V, Arumugam S, Thandavarayan RA, Karuppagounder V, Sreedhar R, Afrin R, Harima M, Suzuki H, Miyashita S, Nomoto M, Sone H, Suzuki K, Watanabe K: Fasting mediated increase in p-BAD(ser155) and p-AKT(ser473) in the prefrontal cortex of mice. Neurosci Lett. 2014 ;579:134-9 .

4.Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Nomoto M, Miyashita S, Suzuki K, Watanabe K: Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. Int Immunopharmacol. 2014 3(2):617-23 .

2013年
1.Arun Prasath Lakshmanana, Meilei Harima, Kenji Suzukib, Vivian Soetiknoa, Masaki Nagatac, Takashi Nakamuraa, Toshihiro Takahashid, Hirohito Sonee, Hiroshi Kawachif, Kenichi Watanabea: The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins. The International Journal of Biochemistry & Cell Biology. 2013 5(2):438-447 .

2.Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Harima M, Suzuki K, Kawachi H, Watanabe K: Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats. J Nutr Biochem. 2013 4(5):796-802 .

3.Soetikno V, Sari FR, Lakshmanan AP, Arumugam S, Harima M, Suzuki K, Kawachi H, Watanabe K: Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. Mol Nutr Food Res. 2013 7(9):1649-59 .

4.Arumugam S, Mito S, Thandavarayan RA, Giridharan VV, Pitchaimani V, Karuppagounder V, Harima M, Nomoto M, Suzuki K, Watanabe K: Mulberry leaf diet protects against progression of experimental autoimmune myocarditis to dilated cardiomyopathy via modulation of oxidative stress and MAPK mediated apoptosis. Cardiovasc Ther. 2013 Dec;31(6):352-62.